THE HELIX NEEDLE.
نویسندگان
چکیده
منابع مشابه
Plasma membrane translocation of a protein needle based on a triple-stranded β-helix motif.
Plasma membrane translocation is challenging due to the barrier of the cell membrane. Contrary to the synthetic cell-penetrating materials, tailed bacteriophages use cell-puncturing protein needles to puncture the cell membranes as an initial step of the DNA injection process. Cell-puncturing protein needles are thought to remain functional in the native phages. In this paper, we found that a b...
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Beta-solenoids are a class of protein nanotube structures that are observed in virulence factors, prion proteins and amyloid fibrils. Here we investigate the compressive strength of the triple-beta-helix solenoid structure found in the cell puncture needle of the bacteriophage T4 virus. We characterize the compressive mechanical strength of this protein nanotube using full-atomistic molecular d...
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The helix-loop-helix (HLH) family of transcription factors comprises >200 members, which have been identified in organisms from yeast to man (reviewed in Littlewood and Evan, 1995; Massari and Murre, 2000). In metazoa, HLH proteins function in the coordinate regulation of gene expression, orchestrating cell cycle control, cell lineage commitment and cell differentiation. An essential role has b...
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ژورنال
عنوان ژورنال: The Lancet
سال: 1902
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(01)51505-6